Research Roundup – January 2016


From time to time, the research wranglers at the Crohnology Blog find ourselves lassoing a few stray stories of IBD-related news. Thus we present another Research Roundup, where we bring those stories back to the corral for your perusal…

  • Avoiding fiber might make flares more likely in Crohn’s patients. A study of 1619 patients with CD and UC shows that patients with Crohn’s “who reported that they did not avoid high fiber foods were ∼40% less likely to have a disease flare than those who avoided high fiber foods”. This is contrary to conventional wisdom that high-fiber foods can trigger flares, although the study does not show a clear causal relationship.
  • Why don’t people take their biologics? A study of people taking anti-TNF medicinines (Remicade, Humira) shows that a quarter of them were ‘non-adherent’ — that is, not taking their meds as prescribed. The main reason was that they were supposed to be taking Humira, which can be injected (or not) at home. Other reasons were shorter disease duration and ’emotional response’. Non-adherence is an important reason why biologic meds stop working over time, so taking the meds as scheduled can help keep them effective.
  • Etanercept may trigger IBD. According to FDA records, some 443 cases of IBD may have been triggered by the anti-TNF drug etanercept (brand name: Enbrel). Etanercept is not approved to treat IBD; patients were taking it for conditions like rheumatoid arthritis.
  • Stem cell transplant is no better than conventional treatment for Crohn’s. A study of patients with severe Crohn’s showed no statistical difference between stem cell transplant and more conventional treatment. One patient who underwent stem cell transplant died.
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